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THE EFFECTS OF DEXTROTHYROXINE IN DIABETES.

W J ZINN, L A SCHLEISSNER

    California Medicine
    |October 1, 1964
    PubMed
    Summary

    Dextrothyroxine lowered cholesterol but worsened diabetes control in patients. This thyroid medication significantly increased blood sugar levels and necessitated adjustments in diabetes management.

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    Area of Science:

    • Endocrinology
    • Metabolic Disorders

    Background:

    • Thyroid hormone analogs are used for lipid management.
    • Potential impact on glucose metabolism requires investigation.

    Purpose of the Study:

    • To evaluate the effect of dextrothyroxine on serum cholesterol and glycemic control in diabetic patients.

    Main Methods:

    • Eighteen diabetic patients received dextrothyroxine (2-8 mg/day) for up to six months.
    • Fasting blood sugar levels were compared before and after treatment.
    • Serum cholesterol levels were monitored.

    Main Results:

    • Dextrothyroxine significantly reduced serum cholesterol levels.
    • A significant elevation in fasting blood sugar levels was observed.
    • 8 of 18 patients showed progressive deterioration of diabetic control, requiring increased medication.
    • One patient developed acidosis; two experienced hypoglycemia.

    Conclusions:

    • Dextrothyroxine exhibits a diabetogenic effect, worsening glycemic control in diabetic patients.
    • The lipid-lowering benefits must be weighed against adverse effects on glucose metabolism.
    • Careful monitoring is essential when using dextrothyroxine in diabetic individuals.
    Keywords:
    ACIDOSISBLOOD SUGARCLINICAL RESEARCHDEXTROTHYROXINEDIABETES MELLITUSHYPERCHOLESTEREMIAHYPOGLYCEMIATOXICOLOGIC REPORT

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