Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long tail kinetics in biophysics?

J F Nagle1

  • 1Department of Biological Science, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.

Biophysical Journal
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Long tail kinetics, observed in complex materials, may also apply to biological systems. Analyzing biological diffusion data with standard methods can lead to inaccurate conclusions due to these long tail effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental support for tilt-dependent theory of biomembrane mechanics.

Physical review letters·2014
Same author

Absence of a vestigial vapor pressure paradox.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2002
Same author

The thermotropic phase behavior of cationic lipids: calorimetric, infrared spectroscopic and X-ray diffraction studies of lipid bilayer membranes composed of 1,2-di-O-myristoyl-3-N,N,N-trimethylaminopropane (DM-TAP).

Biochimica et biophysica acta·2001
Same author

Anomalous swelling in phospholipid bilayers is not coupled to the formation of a ripple phase.

Physical review. E, Statistical, nonlinear, and soft matter physics·2001
Same author

Method for obtaining structure and interactions from oriented lipid bilayers.

Physical review. E, Statistical, nonlinear, and soft matter physics·2001
Same author

Structure of lipid bilayers.

Biochimica et biophysica acta·2000
Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026
Same journal

Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

Biophysical journal·2026
Same journal

Kinesin-5/Cut7 C-terminal tail phosphorylation influence on motor regulation through multi-scale molecular modeling.

Biophysical journal·2026
Same journal

Dynamic conformations of fluorophores on self-labeling protein tags.

Biophysical journal·2026
Same journal

Different actions of RyR2 open and closed channel block explained by a multiscale Ca<sup>2+</sup> release model.

Biophysical journal·2026
Same journal

Membrane Environment Sets the Functional pK<sub>a</sub> of Ionizable Lipids.

Biophysical journal·2026
See all related articles

Area of Science:

  • Biophysics
  • Physical Chemistry
  • Materials Science

Background:

  • Conventional kinetics fail to describe data from complex, disordered materials.
  • Biological media like cytoplasm and biomembranes are complex and disordered.
  • Diffusive motion in biological environments may exhibit long tail kinetics.

Purpose of the Study:

  • Investigate the impact of long tail kinetics on biophysical measurements.
  • Assess the validity of conventional kinetic analysis for biological diffusion data.
  • Highlight potential distortions in interpreting experimental results.

Main Methods:

  • Theoretical analysis of long tail kinetics.
  • Application to fluorescence recovery after photobleaching (FRAP).
  • Application to dynamic light scattering (DLS).

Related Experiment Videos

Main Results:

  • Long tail kinetics significantly affect diffusive motion analysis in biological media.
  • Standard kinetic models applied to long tail data produce distorted results.
  • Biophysical measurements like FRAP and DLS are susceptible to misinterpretation.

Conclusions:

  • Long tail kinetics are crucial for accurately describing diffusion in complex biological systems.
  • Conventional kinetic analyses can yield misleading interpretations of biophysical data.
  • A revised kinetic framework is needed for biological diffusion studies.