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Chlorpromazine induced aggregation of normal human hemoglobin. Electron microscopic evidence
M Bhattacharyya1, A N Ghosh, U Chaudhuri
1Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, India.
Biophysical Chemistry
|October 1, 1992
Abstract:
Normal human hemoglobin exceeding a certain minimum concentration (called critical aggregation concentration) undergoes aggregation in presence of the psychotherapeutic drug chlorpromazine (CPZ). The critical aggregation concentration decreases with the increase of CPZ concentration. Electron micrographs of CPZ-treated hemoglobin clearly indicate that the aggregates of hemoglobin are in filamentous form of average width 75 +/- 8 A. A possible mechanism for such aggregation has been discussed.