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Evidence for an endogenous cholecystokininergic balance in social memory
M Lemaire1, O Piot, B P Roques
1Rhône-Poulenc Rorer Central Research, Centre de Recherches de Vitry-Alfortville, Vitry-Sur-Seine, France.
Abstract:
The cholecystokinin (CCK) peptide family is involved in a variety of physiological processes, including neurotransmission in the brain. Pharmacological responses to CCK are mediated through at least two receptor subtypes termed CCK-A and CCK-B. Studies with CCK agonists suggest a possible role for CCK in cognition. Using selective antagonists and a behavioural recognition test based on the olfactory discriminative capacities of rats, we found that endogenous CCK acting at CCK-A and CCK-B receptors modulates olfactory recognition positively and negatively, respectively. CCK-B receptor antagonists therefore have facilitatory potentialities on memory processes.