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Sulpiride anxiogenic-like effect inhibition by a D1 dopamine receptor antagonist
P Simon1, C Panissaud, J Costentin
1Unité de Neuropsychopharmacologie, URA 1170 du CNRS, Faculté de Médecine et Pharmacie de Rouen, Saint Etienne du Rouvray, France.
Neuroreport
|October 1, 1992
Abstract:
The increased latency to explore a white compartment from a black one into which a mouse has been introduced, appears to be correlated with its anxiety level. In this test, the D2 specific dopamine receptor antagonist (+/-) sulpiride dose dependently (5-40) mg kg-1 i.p.) increased this latency. This effect was suppressed by the D1 specific dopamine receptor antagonist SCH 23390 (25 micrograms kg-1 s.c.) which intrinsically displayed an apparent anxiolytic effect.