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Related Experiment Videos

Circulating transferrin receptor in acute leukemias.

J Kato1, Y Kohgo, H Kondo

  • 1Department of Internal Medicine, Sapporo Medical College, Japan.

International Journal of Hematology
|October 1, 1992
PubMed
Summary

Serum transferrin receptor (s-TR) levels are elevated in acute leukemia patients. s-TR levels decrease to normal ranges upon remission, indicating potential for monitoring leukemia activity.

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Area of Science:

  • Hematology
  • Oncology
  • Biochemistry

Background:

  • Serum transferrin receptor (s-TR) is a protein involved in iron uptake.
  • Elevated s-TR levels have been observed in various proliferative disorders.

Purpose of the Study:

  • To investigate serum transferrin receptor (s-TR) levels in patients with acute leukemia.
  • To assess the correlation between s-TR levels and disease activity/treatment response.

Main Methods:

  • A sandwich radioimmunoassay was used to measure s-TR levels.
  • s-TR levels were compared between normal subjects and acute leukemia patients (AML and ALL).
  • s-TR levels were monitored during remission induction therapy and correlated with leukemic cell counts.

Main Results:

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  • Mean s-TR levels were significantly higher in untreated AML (398 ng/ml) and ALL (479 ng/ml) patients compared to normal subjects (246 ng/ml).
  • s-TR levels decreased to normal ranges (262 ng/ml) in patients who achieved complete remission.
  • A strong positive correlation was observed between s-TR levels and the number of leukemic cells (r = 0.743).

Conclusions:

  • Elevated serum transferrin receptor levels are characteristic of acute leukemia.
  • s-TR levels show promise as a biomarker for assessing acute leukemia activity.
  • Monitoring s-TR levels may be useful for evaluating the effectiveness of leukemia therapy.