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Cephalexin-induced Stevens-Johnson syndrome.

K M Murray¹, M S Camp

¹College of Pharmacy, University of South Carolina, Columbia.

The Annals of Pharmacotherapy

|October 1, 1992

Summary

Cephalexin can cause Stevens-Johnson syndrome (SJS), a severe drug reaction. This case highlights the need to consider cephalexin as a potential cause of SJS.

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Area of Science:

Pharmacovigilance
Dermatology
Internal Medicine

Background:

Stevens-Johnson syndrome (SJS) is a severe mucocutaneous adverse drug reaction.
Early identification and intervention are crucial for managing SJS progression.

Observation:

A case of SJS is presented, linked to cephalexin use.
The patient exhibited fever, arthralgias, malaise, a diffuse violet macular rash, and bullous lesions.
Skin biopsy confirmed SJS, with mucocutaneous ulcers observed.

Findings:

Cephalexin is identified as a potential iatrogenic cause of SJS.
The clinical presentation was consistent with SJS, affecting skin and mucous membranes.
Infectious complications are a significant cause of mortality in SJS.

Implications:

Cephalexin should be recognized as a potential trigger for SJS.
Clinicians should consider cephalexin in the differential diagnosis of SJS.
Awareness of drug-induced SJS is vital for patient safety.

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