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The triglyceride connection in atherosclerosis.

K Geurian1, J B Pinson, C W Weart

  • 1St. Margaret Memorial Hospital, Pittsburgh, PA 15215.

The Annals of Pharmacotherapy
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

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High triglycerides are a risk factor for pancreatitis but their link to heart disease is debated. Lifestyle changes and medication can lower triglycerides, though their benefit for heart health remains controversial.

Area of Science:

  • Cardiovascular Science
  • Metabolic Disorders

Background:

  • Hypertriglyceridemia, elevated serum triglyceride levels, is a known risk factor for pancreatitis.
  • Its role in atherogenesis and coronary heart disease (CHD) is less defined and subject to ongoing debate.

Purpose of the Study:

  • To investigate the proposed mechanisms of triglyceride-induced atherogenesis.
  • To address the controversy surrounding serum triglycerides as a CHD risk factor.
  • To recommend therapeutic strategies for hypertriglyceridemia.

Main Methods:

  • Literature review of studies, reviews, and editorials published since 1976.
  • MEDLINE search using terms "triglyceride" and "hypertriglyceridemia."
  • Selection criteria focused on pathogenesis, CHD risk controversy, and treatment options.

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Main Results:

  • Proposed links between hypertriglyceridemia and atherosclerosis include inverse correlation with HDL, atherogenicity of lipoprotein remnants, potential increase in LDL, and interaction with the fibrinolytic system.
  • Clinical trial results are mixed and open to interpretation.
  • Diet, exercise, weight control, alcohol restriction, and medications effectively lower serum triglyceride levels.

Conclusions:

  • Hypertriglyceridemia is a theoretical CHD risk factor due to atherogenic remnants, inverse HDL relationship, potential LDL changes, and fibrinolytic system interactions.
  • Many trials linking hypertriglyceridemia to CHD do not adequately control for other risk factors.
  • Triglyceride-lowering is recommended for pancreatitis prevention; its role in reducing CHD risk remains controversial.