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Circulating levels of endothelin and atrial natriuretic factor during postnatal life

T Kojima1, Y Isozaki-Fukuda, M Takedatsu

  • 1Department of Pediatrics, Kansai Medical University, Osaka, Japan.

Acta Paediatrica (Oslo, Norway : 1992)
|September 1, 1992
PubMed

Insights

Newborn infants have higher circulating endothelin-1 levels than their mothers, which decrease with age. These levels correlate with atrial natriuretic factor, suggesting endothelin

Area of Science:

  • Neonatal physiology
  • Cardiovascular regulation

Background:

  • Endothelin-1 (ET-1) is a potent vasoconstrictor.
  • Atrial natriuretic factor (ANF) plays a role in fluid and electrolyte balance.
  • Limited data exists on ET-1 and ANF in the neonatal period.

Purpose of the Study:

  • To determine plasma ET-1-like immunoreactivity and ANF concentrations in newborns.
  • To compare these levels between preterm and full-term infants.
  • To investigate the relationship between ET-1 and ANF in neonates.

Main Methods:

  • Measurement of plasma ET-1-like immunoreactivity.
  • Measurement of plasma ANF concentrations.
  • Comparison of levels in neonates and maternal blood.

Main Results:

  • Neonatal plasma ET-1 levels were significantly higher than maternal levels.
  • Highest ET-1 levels were observed on day 1 of life, decreasing with age.
  • No significant difference in ET-1 levels between preterm and full-term infants.
  • A significant positive correlation was found between ET-1 and ANF levels (p < 0.01).

Conclusions:

  • Circulating ET-1 may play a regulatory role in the neonatal cardiovascular system.
  • ET-1 levels are elevated in newborns and decrease postnatally.
  • The correlation between ET-1 and ANF suggests a potential interplay in neonatal cardiovascular homeostasis.

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