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Related Experiment Videos

Lactose feeding during persistent diarrhoea.

M E Penny1, K H Brown

  • 1Instituto de Investigacion Nutricional, Lima, Peru.

Acta Paediatrica (Oslo, Norway : 1992). Supplement
|September 1, 1992
PubMed
Summary
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Identifying lactose intolerance in children with persistent diarrhea is crucial. Malnourished children under 12 months with fever are at higher risk of deterioration when consuming lactose.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Nutritional Science

Background:

  • Lactose intolerance is a complication of diarrhea, particularly in persistent cases among malnourished children.
  • Identifying children needing lactose reduction is vital to avoid unnecessary dietary changes and nutritional disadvantages.

Purpose of the Study:

  • To analyze admission clinical characteristics for predicting clinical outcomes in children with persistent diarrhea on a lactose-containing diet.
  • To evaluate the predictive value of stool reducing substances and lactose breath hydrogen tests (LHBT) for clinical outcomes.

Main Methods:

  • Analysis of clinical characteristics (age, weight-for-height, fever) in 33 children with persistent diarrhea.
  • Assessment of stool reducing substances and LHBT in the same cohort, with management independent of test results.

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Main Results:

  • Eighty-nine percent of children who deteriorated had specific characteristics: age < 12 months, weight-for-height < -2 SD, or fever > 37°C.
  • Simple clinical parameters were more predictive of deterioration than stool tests or LHBT.
  • No reliable method was found to select children who would improve without risk of including those who deteriorated.

Conclusions:

  • Clinical factors like young age, malnutrition, and fever are key indicators of poor outcomes in children with persistent diarrhea on lactose diets.
  • Stool reducing substances and LHBT do not enhance the predictive value of clinical assessment for identifying children at risk.
  • Further research is needed to refine diagnostic and management strategies for lactose intolerance in pediatric persistent diarrhea.