Related Experiment Videos
Vesica fellea--a new substitute for the bladder? An experimental study
1Department of Plastic and Reconstructive Surgery, Hacettepe University, Ankara, Turkey.
British Journal of Urology
|September 1, 1992
Summary
This study demonstrates that autotransplanted gallbladders serve as effective urinary bladders in dogs, maintaining reservoir function without leakage. Renal function was largely preserved, indicating the viability of this surgical approach for bladder reconstruction.
Area of Science:
- Veterinary Surgery
- Urology
- Regenerative Medicine
Background:
- Urinary bladder reconstruction presents surgical challenges.
- Autotransplantation of organs is a complex but potentially viable reconstructive technique.
Purpose of the Study:
- To evaluate the feasibility and efficacy of using autotransplanted canine gallbladders as urinary bladders (neobladders).
- To assess the functional and histological outcomes of gallbladder neobladders in dogs.
Main Methods:
- Eight dogs underwent surgical removal of their urinary bladders and replacement with autotransplanted, vascularized gallbladders.
- Post-operative assessments included blood urea nitrogen (BUN) and creatinine (Cr) measurements, intravenous urography, and histological examination.
Main Results:
- The gallbladder neobladders functioned effectively as reservoirs, demonstrating no urinary leakage.
- Renal function was preserved in six dogs; however, two dogs showed elevated BUN and Cr levels with reduced kidney concentrating ability.
- Histological examination confirmed the perfect structural integrity of the neobladders.
Conclusions:
- Autotransplanted gallbladders are a promising option for urinary bladder replacement in dogs, offering good reservoir function.
- While generally safe, potential impacts on renal function require further investigation and monitoring.