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A TERATOGENIC EFFECT OF A SULPHONAMIDE IN EXPERIMENTAL ANIMALS

G E PAGET, E THORPE

    British Journal of Pharmacology and Chemotherapy
    |October 1, 1964
    PubMed

    Insights

    Sulfamoprine in the diet caused dental and skull abnormalities in offspring of pregnant rats and mice. Rabbits showed no susceptibility to this teratogenic effect, indicating species-specific drug responses.

    Area of Science:

    • Pharmacology
    • Developmental Toxicology
    • Teratology

    Background:

    • Sulfamoprine is a sulfonamide antibiotic.
    • Understanding drug effects during pregnancy is crucial for preventing birth defects.

    Purpose of the Study:

    • To investigate the teratogenic potential of sulfamoprine in pregnant mammals.
    • To determine species-specific responses to sulfamoprine exposure during gestation.

    Main Methods:

    • Pregnant rats and mice were administered sulfamoprine in their diet at varying concentrations (0.025% and above).
    • Pregnant rabbits were also exposed to sulfamoprine.
    • Offspring were examined for developmental abnormalities, particularly of the teeth and skull.

    Main Results:

    • Sulfamoprine exposure resulted in abnormal incisor eruption and skull development in the offspring of rats and mice.
    • Rabbits did not exhibit any teratogenic effects when exposed to sulfamoprine.

    Conclusions:

    • Sulfamoprine exhibits teratogenic effects in rodents, specifically impacting craniofacial and dental development.
    • Rabbits are resistant to the teratogenic actions of sulfamoprine, highlighting interspecies differences in drug metabolism and susceptibility.
    Keywords:
    ABNORMALITIES, DRUG-INDUCEDEXPERIMENTAL LAB STUDYMICEPHARMACOLOGYPREGNANCYPREGNANCY, ANIMALRABBITSRATSSKULLSPECIES SPECIFICITYSULFONAMIDESTOOTH ABNORMALITIESTOXICOLOGIC REPORT

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