Jove
Visualize
Contact Us

Related Experiment Videos

Pulse jitter retards kindling without affecting brain-stimulation reward.

J T Rick1, G Fouriezos

  • 1School of Psychology, University of Ottawa, Ont. Canada.

Brain Research
|September 11, 1992
PubMed
Summary

Electrical brain stimulation can cause seizures. Introducing jitter to pulse timing did not affect self-stimulation behavior but did slow seizure development in rats, suggesting irregularity may inhibit epileptogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bidirectional multisite seizure propagation in the intact isolated hippocampus: the multifocality of the seizure "focus".

Neurobiology of disease·2006
Same author

Short- and long-term effects of interleukin-2 on weight, food intake, and hedonic mechanisms in the rat.

Behavioural brain research·2004
Same author

Strain and gender specific effects in the forced swim test: effects of previous stress exposure.

Stress (Amsterdam, Netherlands)·2003
Same author

Measuring threshold shifts for brain stimulation reward using the method of limits.

Canadian journal of experimental psychology = Revue canadienne de psychologie experimentale·2001
Same author

The substrate for brain-stimulation reward in the lateral preoptic area: III. Connections to the lateral hypothalamic area.

Behavioral neuroscience·2001
Same author

Instability of dentate gyrus field potentials in awake and anesthetized rats.

Hippocampus·1999
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Epilepsy Research

Background:

  • Electrical brain stimulation is used to study reward pathways.
  • Seizure activity may be influenced by the regularity of stimulation pulses.
  • Understanding factors influencing seizure development is crucial for therapeutic interventions.

Purpose of the Study:

  • To investigate the effect of pulse timing regularity on brain stimulation reward.
  • To determine if jitter in stimulation pulses influences seizure development (epileptogenesis).

Main Methods:

  • Rats self-stimulated with lateral hypothalamic electrodes, with and without jittered pulse intervals.
  • Rats were kindled via amygdala stimulation with regularly timed or jittered pulses until motor seizures occurred.

Related Experiment Videos

Main Results:

  • Jittered pulse intervals did not alter charge-duration functions in self-stimulation behavior.
  • Rats kindled with jittered pulses took longer to develop full motor seizures compared to those with regular pulses.

Conclusions:

  • The neural circuitry for self-stimulation is robust to irregular pulse timing.
  • Irregularity in stimulation pulse timing appears to retard the development of seizures, suggesting a role for temporal regularity in epileptogenesis.