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Preservation of energy metabolites by carnitine in the mouse brain under ischemia
1Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Brain Research
|September 11, 1992
Abstract:
Ischemia (decapitation) caused marked changes of energy metabolites in the mouse brain. However, the changes were clearly less severe, when the mouse was pre-treated with L-carnitine. This suggests that L-carnitine may protect the brain from the ischemic attack. Since D-carnitine showed a similar effect, the effects may be due to mechanism(s) other than the 'classical' function of carnitine.