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GCWIND: a microcomputer program for identifying open reading frames according to codon positional G+C content.

D C Shields1, D G Higgins, P M Sharp

  • 1Department of Genetics, Trinity College, Dublin, Ireland.

Computer Applications in the Biosciences : CABIOS
|October 1, 1992
PubMed
Summary
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GCWIND is a new program that identifies protein-coding regions in DNA sequences. It displays base composition and codon positions to highlight potential coding areas.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Identifying protein-coding open reading frames (ORFs) is crucial for understanding gene function.
  • Existing tools like FRAME have limitations in accessibility and implementation.

Purpose of the Study:

  • To introduce GCWIND, a user-friendly microcomputer program for identifying protein-coding ORFs.
  • To provide a tool that visualizes DNA sequence characteristics relevant to coding potential.

Main Methods:

  • GCWIND analyzes DNA sequences on IBM-PC compatible microcomputers.
  • It calculates and displays base composition (%G+C) for all three reading frames.
  • The program identifies and marks potential translation initiation and termination codons on both strands.

Related Experiment Videos

Main Results:

  • GCWIND offers a clear, immediate representation of coding potential within DNA sequences.
  • It facilitates the identification of ORFs by visualizing key sequence features.

Conclusions:

  • GCWIND is an effective tool for the identification of protein-coding open reading frames.
  • The program enhances ORF analysis through accessible visualization of sequence composition and codon data.