Cellology of HLA. 22. Heterogeneity of cellular reactions in negative HLA-D typing

We have demonstrated that in more than half of the mixed lymphocyte reactions, proliferative reactions, in which responders were reacted against HLA-D-compatible homozygous typing cells, were significantly greater than zero. These reactions often masked the true HLA-D identity of the cells under test, as was subsequently shown by primed lymphocyte testing.