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TRANSPLANTATION IMMUNITY OF GESTATIONAL ORIGIN IN INFANT RATS

R E BILLINGHAM, J PALM, W K SILVERS

    Science (New York, N.Y.)
    |January 29, 1965
    PubMed

    Comparison of the survival times of homografts of BN skin on 3-day-old Lewis rats born of mothers of the same isogenic strain with those of BN grafts on infant Lewis hosts that had developed in an F(1) (Lewis x BN) hybrid, gave no evidence of maternally induced tolerance as a result of development in an antigenically alien environment. On the contrary, the significantly shorter median survival time of the grafts on the hybrid-derived Lewis group suggests that sensitization had occurred as a consequence of natural exposure during gestation to small numbers of maternal cells.

    Keywords:
    ANIMALS, NEWBORNEXPERIMENTAL LAB STUDYIMMUNE TOLERANCEMATERNAL-FETAL EXCHANGEPREGNANCYPREGNANCY, ANIMALRATSSKIN TRANSPLANTATIONTRANSPLANTATION IMMUNOLOGYTRANSPLANTATION, HOMOLOGOUS

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