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Related Experiment Videos

Tissue factor as a tumor procoagulant.

L V Rao1

  • 1Department of Medicine, University of California, San Diego 92093.

Cancer Metastasis Reviews
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Tumor cells express tissue factor (TF), a protein initiating blood clotting. This TF activity on tumor cells contributes to Trousseau

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Area of Science:

  • Hematology
  • Oncology
  • Biochemistry

Background:

  • Tissue factor (TF) is a cell surface glycoprotein crucial for initiating the extrinsic coagulation pathway.
  • Tumor cells and homogenates frequently exhibit TF activity, implicated in Trousseau's syndrome.
  • TF expression on tumor cell surfaces is linked to thrombotic events.

Purpose of the Study:

  • To elucidate the role of tissue factor in tumor-associated thrombosis.
  • To understand the mechanisms of TF expression and activity on tumor cells.
  • To explore the regulation of TF activity by plasma inhibitors and its clinical implications.

Main Methods:

  • Immunohistochemical studies to detect TF on tumor cell surfaces.
  • Analysis of tumor cell membrane fragments and shed microvesicles.

Related Experiment Videos

  • Investigation of soluble factors inducing TF expression on host cells.
  • Assessment of TF procoagulant activity modulation and regulation by TF pathway inhibitor.

    • Main Results:

    • Many tumors associated with Trousseau's syndrome express TF on their cell surfaces.
    • Tumor cells shed TF-bearing membrane fragments, activating the clotting system.
    • Tumor-derived soluble factors can induce TF expression on distant host cells.
    • TF procoagulant activity is largely dormant on intact cells but enhanced upon injury.
    • TF pathway inhibitor regulates TF activity by binding TF/VIIa complexes.

    Conclusions:

    • Tumor cell-associated tissue factor plays a significant role in initiating coagulation and promoting thrombosis.
    • TF activity is modulated by cell membrane integrity and regulated by TF pathway inhibitor.
    • Heparin therapy is effective in preventing thrombotic events in Trousseau's syndrome, though mechanisms remain unclear.