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INCREASED SUSCEPTIBILITY OF MICE INFECTED WITH MOUSE ADENOVIRUS TO ESCHERICHIA COLI-INDUCED PYELONEPHRITIS
Abstract:
Mouse adenovirus causes a persistent infection in the mouse kidney that produces extensive mononuclear cell infiltrates in cortex and medulla. Tubular necrosis, dilatation, and occasional collapse occur but no glomerular changes or periglomerular fibrosis have been observed. Acute and chronic adenovirus infection of the kidney predispose the kidney to develop acute pyelonephritis when the mouse is challenged by the intravenous or retrograde route with Escherichia coli.
Insights
Mouse adenovirus causes persistent kidney infections, leading to tubular damage. This adenovirus infection increases susceptibility to secondary Escherichia coli infections, causing acute pyelonephritis.
Area of Science:
- Veterinary Pathology
- Virology
- Immunology
Background:
- Mouse adenovirus establishes persistent infections in the kidney.
- Adenovirus infection causes significant mononuclear cell infiltration in the renal cortex and medulla.
- Pathological changes include tubular necrosis, dilatation, and collapse, without glomerular alterations or periglomerular fibrosis.
Purpose of the Study:
- To investigate the pathological effects of mouse adenovirus in the kidney.
- To determine if adenovirus infection predisposes mice to secondary bacterial infections.
Main Methods:
- Histopathological examination of mouse kidneys infected with adenovirus.
- Experimental challenge with Escherichia coli following adenovirus infection.
Main Results:
- Mouse adenovirus infection leads to persistent renal inflammation and tubular damage.
- Adenovirus-infected kidneys showed increased susceptibility to Escherichia coli.
- Secondary Escherichia coli challenge resulted in acute pyelonephritis.
Conclusions:
- Mouse adenovirus infection causes significant renal pathology.
- Adenovirus-induced kidney damage creates a vulnerability to bacterial infections like pyelonephritis.