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Updated: Jul 7, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
Published on: December 8, 2013
The relation between atherosclerosis and thrombosis
1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.
Background:
The relation between atherosclerosis and thrombosis has been recognized for over a century. Until very recently, however, this pathophysiological association has been largely based on observation with little information available to dissect molecular and cellular mechanism.
Methods And Results:
The known associations between the principal determinants of thrombosis (platelets, fibrin and its proteolytic degradation products, and fibrinolytic enzymes) and atherosclerosis; the regulation of thrombotic determinants by cytokines and growth factors important in atherogenesis; and the modulation of thrombotic determinants by atherogenic lipoproteins, especially lipoprotein(a), are discussed.
Conclusions:
Within this conceptual framework, clear molecular and cellular mechanisms emerge, and a better basic understanding of the thrombotic determinants of atherogenesis can be developed.
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