Association of haptoglobin types with serum lipids and apolipoproteins in a Chinese population

Association of haptoglobin types with serum lipids and apolipoprotein levels was investigated in a healthy Chinese population of both sexes (n = 679) in Singapore. The frequency of Hp1 and Hp2 was found to be 0.30 and 0.70, respectively. The distribution of haptoglobin phenotypes was at Hardy-Weinberg equilibrium in this population. There was an excess of Hp2 in individuals with the upper two quartiles of serum total cholesterol levels compared to those with the lower two quartiles in both sexes (X1(2): 11.84; P less than 0.001). Subjects with Hp 2-2 had significantly higher serum total and LDL cholesterol levels (243.8 +/- 2.83 and 165.9 +/- 2.48 mg/dl) compared to those in other haptoglobin types (230.7 +/- 2.58 and 154.9 +/- 2.49 mg/dl), respectively (P less than 0.001 and 0.002) after adjustments for age, sex and BMI. No other lipid (HDL cholesterol and triglyceride) and apolipoprotein (apo A-I, A-II and B) traits were associated with haptoglobin types. ANOVA statistics using age, sex and BMI as covariates showed that 1.8% of total variability of serum total cholesterol and 2.1% of serum LDL cholesterol could be explained by haptoglobin types (P 0.008 and 0.003, respectively). It is concluded that haptoglobin polymorphism is significantly associated with serum total and LDL cholesterol levels in this Chinese population.