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Related Experiment Videos

Generalized elastosis perforans serpiginosa in Down's syndrome.

B O'Donnell1, P Kelly, P Dervan

  • 1Regional Centre of Dermatology, Mater Hospital, Dublin, Ireland.

Clinical and Experimental Dermatology
|January 1, 1992
PubMed
Summary

Elastosis perforans serpiginosa (EPS) is a rare skin condition involving elastic tissue extrusion. This case highlights an extensive EPS presentation in an adult with Down

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Area of Science:

  • Dermatology
  • Genetics
  • Pathology

Background:

  • Elastosis perforans serpiginosa (EPS) is a rare disorder of epidermal perforation.
  • Characterized by the extrusion of dermal elastic tissue through the epidermis.
  • Etiology is unknown, but evidence suggests an abnormality of elastic tissue.

Observation:

  • Three forms of EPS exist: idiopathic, iatrogenic, and associated with genetic connective tissue disorders.
  • Cutaneous lesions typically appear between ages 6-20 years and persist for 6 months to 5 years.
  • Lesions can be localized or disseminated.

Findings:

  • Presents a case of a 28-year-old woman with recent onset of unusually extensive EPS.
  • The patient had co-existing Down's syndrome and secondary sclerosing cholangitis.

Related Experiment Videos

  • This case expands the understanding of EPS presentation in adults and its potential associations.

    • Implications:

    • Suggests a need for broader age consideration in EPS diagnosis.
    • Highlights potential links between EPS, genetic disorders like Down's syndrome, and other systemic conditions.
    • Further research into the underlying elastic tissue abnormalities in EPS is warranted.