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Related Experiment Videos

Bullous secondary syphilis.

P Lawrence1, N Saxe

  • 1Groote Schuur Hospital/University of Cape Town, South Africa.

Clinical and Experimental Dermatology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Vesicular eruptions are not typically associated with secondary syphilis in adults. However, this case demonstrates a bullous eruption in an adult with secondary syphilis, rapidly resolving with penicillin treatment.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Syphilology

Background:

  • Traditional syphilology texts state vesicular eruptions exclude secondary syphilis in adults.
  • Vesicular and bullous lesions are documented in congenital syphilis.
  • Rare adult cases of secondary syphilis with vesicular/pustular eruptions exist.

Observation:

  • A patient presented with a bullous-pemphigoid-like rash.
  • The patient also had a positive Venereal Disease Research Laboratory (VDRL) test, indicating syphilis.
  • This presentation challenged conventional understanding of secondary syphilis manifestations.

Findings:

  • The patient received a course of procaine penicillin treatment.
  • The bullous eruption resolved rapidly and permanently following treatment.

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  • This suggests penicillin is effective for such rare presentations of secondary syphilis.

    • Implications:

    • This case expands the spectrum of recognized cutaneous manifestations of secondary syphilis in adults.
    • It highlights the importance of considering syphilis in adult patients with unusual blistering eruptions.
    • Effective treatment with penicillin underscores the continued efficacy of this antibiotic for syphilis.