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In vitro fertilization in the natural cycle.
Bailliere'S Clinical Obstetrics and Gynaecology
|June 1, 1992
Summary
Natural cycle in vitro fertilization (IVF) is attractive but initially inefficient. Improvements have increased live birth rates, though pregnancy rates per embryo remain lower than natural conception.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization
- Human Reproduction
Background:
- The concept of natural cycle in vitro fertilization (IVF) was introduced in 1980.
- Early attempts to replicate natural cycle IVF faced challenges with efficiency and broader applicability.
- The attractiveness of natural cycle IVF prompted further research and technique evaluation.
Purpose of the Study:
- To evaluate the efficacy and efficiency of natural cycle IVF.
- To identify and implement improvements in the natural cycle IVF technique.
- To compare pregnancy rates with spontaneous in vivo conception.
Main Methods:
- Initial evaluation of natural cycle IVF in patients with tubal lesions.
- Introduction of procedural changes over four years to enhance efficiency.
- Tracking of procedural losses and pregnancy outcomes at each stage.
Main Results:
- Initial success was limited to patients with specific infertility indications (tubal lesions).
- Procedural modifications significantly improved the efficiency of natural cycle IVF.
- Take-home baby rates were enhanced, but overall pregnancy rates per embryo did not change.
Conclusions:
- Natural cycle IVF efficiency has been improved through procedural modifications.
- Current natural cycle IVF pregnancy rates per embryo are still lower than spontaneous rates.
- Future advancements in culture techniques and gamete biology are expected to improve outcomes.