Related Experiment Video
Updated: Sep 1, 2026

Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates
Published on: September 6, 2017
[Major cardiomegalies of the newborn]
Insights
Massive heart enlargement in newborns, a rare condition, was linked to several serious cardiac and neurological issues. Early diagnosis is crucial for appropriate treatment and to prevent unnecessary surgeries.
Area of Science:
- Neonatal cardiology
- Pediatric cardiovascular diseases
- Congenital heart anomalies
Context:
- Massive heart enlargement, defined by a cardio-thoracic ratio (C.T.R.) ≥ 0.75, is a rare finding in neonates.
- This condition represents 5% of all congenital cardiac malformations in newborns.
Purpose:
- To identify the causes of massive heart enlargement in neonates.
- To propose a diagnostic scheme for early recognition of treatable conditions.
- To prevent inappropriate surgical interventions.
Summary:
- Seventeen neonates presented with massive heart enlargement within the first ten days of life.
- Identified causes included Ebstein's anomaly (6 cases), cerebral arteriovenous aneurysms (6 cases), primary endocardial fibroelastosis (2 cases), and single cases of septic pericarditis, transposition of great arteries, and pulmonary atresia with intact ventricular septum.
- A diagnostic algorithm is suggested to differentiate between these conditions.
Impact:
- Facilitates early diagnosis of critical neonatal cardiac conditions.
- Aids in guiding appropriate clinical management and surgical decisions.
- Reduces the risk of ineffective or harmful surgical procedures in neonates with massive cardiomegaly.
Abstract:
Massive enlargement of the heart measured by cardio-thoracic ratio (C.T.R. greater than or equal to 0,75) was found in 17 neonates in the first ten days of their life. The diseases causing this rare anomaly (5% of all newborns with cardiac malformations) were: Ebstein's disease (6 cases), cerebral arterio-venous aneurism (6 cases), primary endocardial fibro-elastosis (2 cases), septic pericarditis, transposition of great arteries and pulmonary atresia with intact ventricular septum (1 case of each). A diagnosis scheme is proposed in order to recognize early tractable diseases and to avoid inadequate surgical indications.
Related Concept Videos
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Fetal Circulation
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Cardiovascular System Abnormal Findings II: Auscultation
Abnormal Heart Sounds
Gallops:
Mitral Regurgitation I: Introduction
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests

