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Updated: Jun 29, 2026

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
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Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

Published on: January 1, 2008

CONTACT-INDUCED CYTOTOXICITY BY LYMPHOID CELLS CONTAINING FOREIGN ISOANTIGENS

E MOELLER

    Science (New York, N.Y.)
    |February 19, 1965
    PubMed

    In tissue culture, immune lymph node cells containing foreign histocompatibility antigens of the H-2 type exert marked cytotoxic effects on tumor cells incompatible with the H-2 antigen. An equally pronounced effect is obtained when normal allogeneic and semi-isologous lymphoid cells of F(1) hybrids are caused to aggregate around the target tumor cells by treating the cultures with either heat-inactivated rabbit antiserum to mouse cells or phytohemagglutinin. Isologous lymph node cells have no effect. Thus, aggregation of lymphoid cells and target cells is a necessary but insufficient requirement for cytotoxicity in vitro; in addition, close contact must be established between histoincompatible cells.

    Keywords:
    ANTIGENSCULTURE MEDIAEXPERIMENTAL LAB STUDYIMMUNE SERUMSIMMUNIZATIONLYMPH NODESMETHYLCHOLANTHRENEMICENEOPLASM IMMUNOLOGYNEOPLASM TRANSPLANTATIONPLANT AGGLUTININSRABBITSSARCOMA, EXPERIMENTALTISSUE CULTURETOXICOLOGIC REPORT

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