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Related Experiment Videos

Hageman factor deficiency presentation and implications for management.

K Harper1, M L Friedland

  • 1St. Vincent's Medical Center, Bridgeport.

Connecticut Medicine
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

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Factor XII deficiency, an inherited coagulation disorder, presents diagnostic challenges. Management requires specific monitoring methods, especially during heparin therapy, to ensure patient safety.

Area of Science:

  • Hematology
  • Coagulation Disorders

Background:

  • Factor XII deficiency is an inherited autosomal recessive coagulation disorder.
  • It presents diagnostic challenges in patient management.
  • Clinical suspicion arises from prolonged activated partial thromboplastin time (APTT) with normal prothrombin time (PT) and bleeding time.

Purpose of the Study:

  • To discuss the clinical significance and management of Factor XII deficiency.
  • To highlight diagnostic confirmation methods.
  • To review therapeutic monitoring strategies, particularly during heparinization.

Main Methods:

  • Clinical suspicion based on coagulation profile (prolonged APTT, normal PT, normal bleeding time).
  • Diagnostic confirmation via normalization of PTT with aged plasma and factor assay.

Related Experiment Videos

  • Monitoring heparin therapy using chromogenic heparin assay, citrated thrombin time, and recalcified thrombin time.

    • Main Results:

    • Factor XII deficiency can be suspected clinically and confirmed through specific laboratory tests.
    • Effective monitoring strategies exist for heparin therapy in patients with this deficiency.
    • Two illustrative cases are presented to demonstrate clinical scenarios.

    Conclusions:

    • Understanding Factor XII deficiency is crucial for accurate diagnosis and effective patient management.
    • Specific laboratory tests are essential for confirmation.
    • Appropriate monitoring is vital when managing patients with Factor XII deficiency, especially during anticoagulation therapy.