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Effect of Norplant-2 rods on haemostatic function
S Kuldip1, O A Viegas, S L Koh
1Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Contraception
|July 1, 1992
Summary
Norplant-2 contraceptive rods may alter blood clotting factors and reduce fibrinolysis with prolonged use. While not causing hypercoagulability, further research is needed on increased platelets and aggregation.
Area of Science:
- Reproductive Health
- Hematology
- Pharmacology
Background:
- Norplant-2 rod implant is a progestin-only contraceptive method.
- Understanding its long-term effects on hemostasis is crucial for women's health.
Purpose of the Study:
- To investigate the impact of Norplant-2 rod implant use on the hemostatic function in Singaporean women.
- To assess changes in coagulation factors and fibrinolytic activity.
Main Methods:
- A longitudinal study involving 100 Singaporean women using Norplant-2.
- Monitoring of hemostatic parameters over the duration of implant use.
Main Results:
- Prolonged Norplant-2 use led to decreased vitamin K-dependent Factors II and VII.
- A trend towards lowered fibrinolytic activity was observed.
- No contribution to a hypercoagulable state was indicated.
Conclusions:
- Norplant-2 implant system does not appear to induce hypercoagulability.
- Increased platelets and accelerated platelet aggregation warrant further investigation for platelet activation.