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Related Experiment Videos

Reversible endothelial changes in the monkey cornea.

M C Madigan1, B A Holden

  • 1Cornea and Contact Lens Research Unit, School of Optometry, University of New South Wales, Sydney, Australia.

Cornea
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

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The vascular response to long-term extended contact lens wear.

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Contact lens wear in monkeys caused reversible corneal endothelial changes, similar to human responses. This suggests the Macaca fascicularis monkey is a suitable model for studying eye inflammation and endothelial bleb responses.

Area of Science:

  • Ophthalmology
  • Primate Research
  • Corneal Science

Background:

  • Extended contact lens wear can induce corneal changes.
  • Anterior eye inflammation is a known complication in humans wearing contact lenses.

Purpose of the Study:

  • To investigate the effects of extended contact lens wear on the corneal endothelium in Macaca fascicularis monkeys.
  • To evaluate the monkey as a model for human responses to contact lens wear and anterior eye inflammation.

Main Methods:

  • Slit lamp biomicroscopy and contact specular microscopy were used to examine corneal endothelial changes.
  • Observations were made in Macaca fascicularis monkeys undergoing extended contact lens wear.

Main Results:

  • Reversible corneal endothelial changes were observed in monkeys wearing contact lenses.

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  • In some monkeys, these changes were associated with anterior eye inflammation, mimicking human responses.
  • Two monkeys exhibited endothelial changes without apparent inflammation, resembling the human transient endothelial bleb response.

    • Conclusions:

    • The Macaca fascicularis monkey demonstrates corneal endothelial responses similar to humans during extended contact lens wear.
    • This primate model may be valuable for further research into endothelial responses during anterior eye inflammation and the transient endothelial bleb response.