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Related Experiment Videos

Infectious crystalline keratopathy with ring opacity.

J M McDonnell1, D C Gritz, D Hwang

  • 1Doheny Eye Institute, University of Southern California, School of Medicine, Los Angeles 90033.

Cornea
|September 1, 1992
PubMed
Summary

Infectious crystalline keratitis caused by Streptococcus mitis can present as an annular infiltrate, a finding not previously documented. Prompt treatment with topical penicillin and corticosteroid tapering led to resolution.

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Area of Science:

  • Ophthalmology
  • Microbiology
  • Infectious Diseases

Background:

  • Herpetic keratitis is a common corneal infection often treated with antivirals and steroids.
  • Steroid use can predispose patients to secondary infections, including bacterial keratitis.
  • Infectious crystalline keratitis (ICK) is a rare form of bacterial keratitis characterized by stromal opacities.

Observation:

  • A physician with presumed herpetic keratitis presented with an annular stromal infiltrate and crystalline opacities.
  • Cultures from corneal scrapings and biopsies identified Streptococcus mitis.
  • Histopathology revealed aggregates of cocci within the corneal stroma.

Findings:

  • This case suggests ICK can manifest with an annular infiltrate.
  • Experimental inoculation in rabbits produced crystalline infiltrates but not annular opacities.

Related Experiment Videos

  • Corticosteroids influenced the clinical and histopathological presentation in the rabbit model.

    • Implications:

    • Recognizing ICK as a cause of annular infiltrates is crucial for accurate diagnosis and treatment.
    • This finding expands the differential diagnosis for infectious keratitis.
    • Understanding the role of corticosteroids in modulating ICK presentation is important for patient management.