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Adoptive transfer of experimental autoimmune uveoretinitis in HgCl2 injected rats
A Saoudi1, B Bellon, Y de Kozak
1Pathologie rénale et vasculaire, INSERM U28, Hôpital Broussais, Paris, France.
Current Eye Research
|January 1, 1992
Abstract:
We previously demonstrated that mercuric chloride (HgCl2) injected-(Lewis x Brown-Norway) F1 rats are protected against experimental autoimmune uveoretinitis (EAU) induced by active immunization with the retinal S-antigen (S-Ag). To better understand the mechanisms of the protection promoted by HgCl2, we studied the effect of HgCl2-induced autoimmune disease on transferred EAU. We demonstrate herein that HgCl2 has no effect on adoptively transferred EAU. Therefore, the HgCl2-induced autoimmune disease does not affect effector S-Ag specific T cells activated in vitro but acts at an earlier stage.