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Pinealitis coincident with recurrent uveitis: immunohistochemical studies
C M Kalsow1, A E Dwyer, A W Smith
1Department of Ophthalmology, School of Medicine and Dentistry, University of Rochester, NY 14642.
Current Eye Research
|January 1, 1992
Summary
This study observed pinealitis (pineal gland inflammation) in a horse with equine recurrent uveitis. This finding suggests pineal gland pathology may occur alongside human uveitis, supporting animal models.
Area of Science:
- Ophthalmology
- Immunology
- Veterinary Pathology
Background:
- Experimental autoimmune uveitis models suggest pinealitis often accompanies uveitis.
- Direct evidence of pineal pathology in human uveitis cases is lacking.
- Equine recurrent uveitis offers a model for studying co-occurring eye and pineal gland diseases.
Purpose of the Study:
- To investigate pineal gland pathology in horses with naturally occurring uveitis.
- To determine if pinealitis is present in equine recurrent uveitis.
- To compare findings with experimental autoimmune uveitis models.
Main Methods:
- Histopathological examination of eye and pineal gland tissues from a mare with equine recurrent uveitis.
- Immunohistochemistry to detect immunoglobulin and MHC Class II antigens.
- Analysis of infiltrating and resident cells in affected tissues.
Main Results:
- Pinealitis was identified in the affected mare.
- Immunoglobulin and MHC Class II antigens were detected on infiltrating and resident cells in both the eye and pineal gland.
- Findings indicate an inflammatory process affecting both organs.
Conclusions:
- The presence of pinealitis in equine recurrent uveitis supports the relevance of animal models for studying uveitis.
- This study provides direct evidence of pineal pathology accompanying naturally occurring uveitis.
- Pinealitis may be a coincidental finding in some cases of human uveitis.