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Rapid left ventricular filling in untreated hypertensive subjects with or without left ventricular hypertrophy
G Licata1, R Scaglione, G Parrinello
1Institute of Medical Pathology, University of Palermo, Italy.
Insights
In hypertensive patients, body mass index (BMI), age, and 24-hour blood pressure significantly impair diastolic filling, not left ventricular hypertrophy (LVH). These factors are key to understanding abnormal PFR in hypertension.
Area of Science:
- Cardiology
- Hypertension Research
- Diastolic Function Assessment
Background:
- Diastolic filling is crucial for cardiac function.
- Hypertension can lead to cardiac abnormalities.
- Understanding determinants of diastolic dysfunction is vital.
Purpose of the Study:
- To investigate the independent contribution of various factors (age, BMI, blood pressure, LVH) on diastolic filling in hypertensive patients.
- To identify major determinants of abnormal PFR in never-treated hypertensive individuals.
Main Methods:
- Studied 34 never-treated hypertensive patients and 15 healthy controls.
- Excluded subjects with other cardiac, renal, or psychiatric conditions.
- Subgrouped hypertensives based on left ventricular hypertrophy (LVH) presence.
Main Results:
- Hypertensive patients showed significantly decreased PFR and increased tPFR compared to controls.
- PFR did not differ significantly between hypertensive subgroups with or without LVH.
- PFR inversely correlated with BMI, age, and 24-hour SBP/DBP.
Conclusions:
- BMI, age, and 24-hour mean blood pressure are primary determinants of PFR abnormalities in hypertensive patients.
- Left ventricular mass index (LVMI) was not a significant determinant of PFR in this cohort.
- These findings highlight key modifiable factors impacting diastolic function in hypertension.
Abstract:
In this study, independent contribution of age, HR, BMI, casual and ambulatory blood pressure, LVM and LVEF in evaluating diastolic filling have been investigated in 34 never-treated hypertensive patients and in 15 healthy normotensive subjects. All the subjects were free from coronary artery disease, valvular disease, heart failure, renal disease and psychiatric problems. All the hypertensive subjects (never treated) were subgrouped according to presence or absence of LVH. The PFR decreased significantly and tPFR increased significantly in hypertensive patients in comparison with normotensive subjects and they did not change in the presence vs absence of LVH. The PFR was inversely correlated with BMI, age, 24-h mean SBP and with 24-h DBP. In multiple regression analysis, PFR decreased with BMI, age, 24-h mean SBP and DBP but not with LVMI. These results suggest that BMI, age and 24-h mean blood pressure were the major determinants of PFR abnormalities in hypertensive patients.