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Related Experiment Videos

Activin can generate ectopic axial structures in chick blastoderm explants.

T Ziv1, Y Shimoni, E Mitrani

  • 1Institute of Life Sciences, Hebrew University of Jerusalem, Israel.

Development (Cambridge, England)
|July 1, 1992
PubMed
Summary

Activin acts as an instructive signal, inducing ectopic embryonic axes in chick blastulae. This suggests normal axis formation involves an inhibitory process to ensure a single axis develops.

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Area of Science:

  • Developmental biology
  • Embryology
  • Cell fate determination

Background:

  • Activin's role in axial structure formation in chick blastulae was previously shown.
  • Activin beta-B is transcribed during axial mesoderm induction.
  • The instructive versus permissive role of activin was unclear.

Purpose of the Study:

  • To determine if activin is an instructive inducer of axial structures.
  • To investigate the mechanism of single axis formation during chick development.

Main Methods:

  • Exposure of chick blastulae to activin-containing medium (ACM).
  • Observation of ectopic embryonic axis formation.
  • Analysis of developmental processes regulating axis formation.

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Main Results:

  • Activin-containing medium (ACM) induced ectopic embryonic axis formation.
  • ACM demonstrated instructive induction, altering cell fate.
  • Evidence suggests a controlled inhibitory process limits axis formation in normal development.

Conclusions:

  • Activin acts as an instructive inducer, capable of changing cell fate.
  • A regulated inhibitory mechanism ensures the formation of a single embryonic axis during normal development.