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[Liver extract effect on liver microsomal system and on an experimental model of intoxication]
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1977
Abstract:
A lyophilized liver extract (FLR) lengthens hexobarbital action in control rats ; it decreases slightly the induction of hepatic microsomal enzymes and normalizes diphenylhydantoin protection against electroshock seizure in phenobarbital-treated animals ; in the event of a CC14 intoxication, this extract reestablishes values close to normal for mebubarbital metabolism in mice and for BSP clearance in rats. FLR could act in regularizing drug metabolism.