[Effect of theophylline on diuresis and the physiological proteinuria of white rats]
Related Experiment Video
Updated: Oct 23, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Abstract:
The present study considers the quantitative variations of the physiologic proteinuria with theophyllin in the rat. The urins are collected, during 8 hours, every Rat being its own reference. The single theophyllin injection (20 mg/kg) induces an increased diuresis (+ 42,1 %) and proteinuria (+ 73,7 %). The repetitive theophyllin injections (during 5 days) confirms this constation. The hypothesis of a modification of the permeability of the glomerular barrier to proteic macromolecules is proposed to agree this result.
Related Concept Videos
Drug Elimination by Renal Route: Tubular Secretion
Antihypertensive Drugs: Action of Diuretics
Antihypertensive Drugs: Thiazide-Class Diuretics
Renal Drug Excretion: Tubular Secretion
Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa
The pKa of a drug,...
Physiology of the Genitourinary System III: Urine Concentration and Dilution

