ENZYMATIC ACTION ON THE CAPSULAR MATERIAL PRODUCED BY PSEUDOMONAS AERUGINOSA OF CYSTIC FIBROSIS ORIGIN

Doggett, Robert G. (Texas Institute for Rehabilitation and Research, Houston), Gunyon M. Harrison, Richard N. Stillwell, and Everett S. Wallis. Enzymatic action on the capsular material produced by Pseudomonas aeruginosa of cystic fibrosis origin. J. Bacteriol. 89:476-480. 1965.-An enzymatic study of the action of alpha- and beta-amylases on the slime envelope produced by Pseudomonas aeruginosa originating from patients with cystic fibrosis (CF) has been reported. It has been shown that these two enzymes in combination prevent the formation of the abnormal ethanol-benzene insoluble mucoid present in the slime layer of the above organism of CF origin. Evidence is also given which suggests that this organism can serve as a tool for studies of chemical abnormalities in the mucous metabolism of CF individuals.