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Active and inactive renin after exercise.

M Ikeda1, M Matsusaki, A Kinoshita

  • 1Department of Internal Medicine, Fukuoka University School of Medicine, Japan.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1992
PubMed
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Graded exercise significantly increases active renin plasma concentrations in healthy men, with higher intensities yielding greater increases. Inactive renin levels remained unchanged, suggesting sympathetic nerve activity influences active renin release or conversion.

Area of Science:

  • Exercise Physiology
  • Renal Physiology
  • Endocrinology

Background:

  • The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure regulation.
  • Understanding how physiological stimuli like exercise affect renin activity is important for cardiovascular health research.

Purpose of the Study:

  • To investigate the impact of graded exercise intensities on plasma concentrations of active and inactive renin in healthy men.
  • To explore the relationship between exercise-induced changes in renin and other key hormones and metabolites.

Main Methods:

  • Seven healthy males performed 10-minute exercise bouts on a cycle ergometer at 30%, 50%, 80%, and 87% of VO2max.
  • Plasma active and inactive renin concentrations were measured using direct immunoradiometric assays.

Related Experiment Videos

  • Concentrations of noradrenaline, adrenaline, aldosterone, and lactate were also assessed.

    • Main Results:

    • Active renin concentrations increased dose-dependently with exercise intensity, rising 1.2 to 4.6 times above control levels.
    • Plasma concentrations of noradrenaline increased significantly at all exercise stages.
    • Adrenaline, aldosterone, and lactate levels were elevated only at higher exercise intensities (≥50% VO2max).

    Conclusions:

    • Graded exercise progressively elevates plasma active renin concentrations in healthy individuals.
    • Sympathetic nervous system activation, indicated by increased noradrenaline, likely contributes to the rise in active renin during exercise.
    • Inactive renin levels appear unaffected by acute exercise in this study population.