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PRODUCTION OF HERITABLE PARTIAL STERILITY IN THE MOUSE BY METHYL METHANESULPHONATE

H JACKSON, M PARTINGTON, A L WALPOLE

    British Journal of Pharmacology and Chemotherapy
    |December 1, 1964
    PubMed

    Insights

    Methyl methanesulphonate causes heritable genetic damage in mice, leading to reduced fertility in offspring. This study suggests a practical method for testing drug-induced genetic effects.

    Area of Science:

    • Toxicology
    • Genetics
    • Reproductive Biology

    Background:

    • Methyl methanesulphonate (MMS) is a chemical agent.
    • Assessing the reproductive and genetic toxicity of chemical compounds is crucial for public health and safety.

    Purpose of the Study:

    • To investigate the potential of methyl methanesulphonate to induce transmissible genetic damage in mice.
    • To evaluate a practical method for testing potential genetic effects of chemical substances.

    Main Methods:

    • Male mice were administered a single dose of methyl methanesulphonate (50 mg/kg, intraperitoneally).
    • F(1) and F(2) progeny were assessed for partial and complete sterility after mating with fertile partners.

    Main Results:

    • Partial sterility was observed in the F(1) generation.
    • Both partial and complete sterility were encountered in the F(2) generation.
    • The results indicate that a substerilizing dose of methyl methanesulphonate can cause heritable genetic damage.

    Conclusions:

    • Methyl methanesulphonate induces transmissible genetic damage in mice.
    • The experimental procedure is a viable method for screening drugs for potential genetic effects.
    • This study highlights the importance of evaluating the long-term genetic consequences of chemical exposure.
    Keywords:
    EXPERIMENTAL LAB STUDYGENETICSMICEPHARMACOLOGYSTERILITY, MALESULFONIC ACIDSTOXICOLOGIC REPORT

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