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Related Experiment Videos

[Autologous and allogenic human rosettes].

J M Lang, S Mayer

    Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
    |January 1, 1977
    PubMed
    Summary

    Human T lymphocytes can form spontaneous rosettes with red blood cells. Allogeneic rosettes are more common than autologous rosettes, even with rare Bombay blood types.

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    Area of Science:

    • Immunology
    • Cell Biology

    Context:

    • Human peripheral blood T lymphocytes exhibit spontaneous rosette formation with red blood cells in vitro.
    • This phenomenon involves interactions between lymphocytes and autologous (self) or allogeneic (non-self) red blood cells.

    Purpose:

    • To investigate the characteristics of spontaneous T lymphocyte rosette formation with autologous and allogeneic red blood cells.
    • To compare the frequency of autologous versus allogeneic rosettes.
    • To examine rosette formation involving rare Bombay blood type red blood cells.

    Summary:

    • A proportion of T lymphocytes form spontaneous rosettes with red blood cells.
    • The percentage of allogeneic rosettes observed was higher than that of autologous rosettes.
    • Red blood cells of the Bombay blood type demonstrated binding capability with allogeneic lymphocytes, though the Bombay donor showed a low percentage of auto-rosettes.

    Impact:

    • Provides insights into T lymphocyte interactions with red blood cells.
    • Highlights differences in autologous and allogeneic rosette formation.
    • Characterizes the behavior of rare Bombay blood type cells in lymphocyte rosette assays.

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