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Updated: Jun 30, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
COXSACKIE A9 VIRUS: MUTATION FROM DRUG DEPENDENCE TO DRUG INDEPENDENCE
Abstract:
During the multiplication of Coxsackie A9 virus dependent on 2 - (alpha - hydroxybenzyl) - benzimidazole there arise some drug-independent virus particles, which are either drug-resistant or drug-sensitive. We studied the properties of such revertant particles under conditions which did not favor the selection of resistant over sensitive virus particles. These particles exhibited a wide range of responses to 2-(alpha-hydroxybenzyl)-benzimidazole, from high sensitivity to high resistance. Subclones showed the same degree of sensitivity or resistance as the respective parent clones.
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