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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

LESIONS IN THE MEDIAL FOREBRAIN BUNDLE: DELAYED EFFECTS ON SENSITIVITY TO ELECTRIC SHOCK

J A HARVEY, C E LINTS

    Science (New York, N.Y.)
    |April 9, 1965
    PubMed

    Insights

    Bilateral lesions in the medial forebrain bundle in rats caused increased pain sensitivity and reduced brain serotonin. These delayed effects suggest central denervation supersensitivity may be responsible.

    Area of Science:

    • Neuroscience
    • Neurobiology
    • Behavioral Science

    Background:

    • The medial forebrain bundle (MFB) is crucial for reward and motivation.
    • Lesions in the MFB can lead to significant behavioral and neurochemical changes.

    Purpose of the Study:

    • To investigate the behavioral and neurochemical consequences of bilateral MFB lesions in rats.
    • To explore the potential role of central denervation supersensitivity in these effects.

    Main Methods:

    • Induction of bilateral lesions in the medial forebrain bundle of rats.
    • Assessment of pain sensitivity using the jump threshold.
    • Measurement of brain serotonin concentration.

    Main Results:

    • Lesioned rats exhibited a lowered jump threshold, indicating increased sensitivity to electric shock.
    • A significant decrease in brain serotonin concentration was observed in lesioned rats.
    • Both behavioral and neurochemical changes showed a delayed onset and gradual development.

    Conclusions:

    • Bilateral MFB lesions induce delayed hypersensitivity to pain and reduced brain serotonin.
    • The time course of these effects suggests a link to nerve degeneration and central denervation supersensitivity.
    Keywords:
    BEHAVIOR, ANIMALBRAIN CHEMISTRYBRAIN PHYSIOLOGYCONVULSIONSELECTRICITYELECTROSHOCKEXPERIMENTAL LAB STUDYHYPOTHALAMUSNERVE DEGENERATIONNEUROSURGERYPATHOLOGYRATSSEROTONINSTEREOTAXIC TECHNICS

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