Related Experiment Videos
Clozapine has sub-micromolar affinity for 5-HT1A receptors in human brain tissue
1Department of Biomedical Science, University of Sheffield, UK.
European Journal of Pharmacology
|October 20, 1992
Abstract:
The affinities of a range of antipsychotic drugs at human hippocampal 5-HT1A receptors, defined by specific [3H]8-OH-DPAT binding, were determined. Clozapine demonstrated the highest affinity; all other antipsychotics studied demonstrated pK(i) values below 6.0 5-HT1A receptors are found on cortical glutamatergic neurons, a dysfunction of which may occur in schizophrenia. Binding at this site indicates a possible mechanism contributing to the unique efficacy of clozapine in the treatment of some schizophrenic patients.