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Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Adaptive Mechanisms in Cancer Cells

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Cancer Prevention

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Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jun 11, 2026

Cell-Free DNA Integrity Analysis in Urine Samples

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

CIRCULATING DNA AS A POSSIBLE FACTOR IN ONCOGENESIS.

A BENDICH, T WILCZOK, E BORENFREUND

Science (New York, N.Y.)

|April 16, 1965

Summary

Tumor-inducing polyoma virus and pneumococcal transforming DNA remain active in mouse blood after injection. This suggests circulating tumorigenic DNA may contribute to the metastatic spread of cancer.

Keywords:

BIOLOGICAL TRANSPORT BLOOD DNA, VIRAL EXPERIMENTAL LAB STUDY INJECTIONS, INTRAPERITONEAL INJECTIONS, INTRAVENOUS METABOLISM MICE NEOPLASM ETIOLOGY NEOPLASM METASTASIS PHOSPHORUS ISOTOPES POLYOMA VIRUS RADIOMETRY TRITIUM

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Last Updated: Jun 11, 2026

Cell-Free DNA Integrity Analysis in Urine Samples

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Published on: January 5, 2017

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Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

Area of Science:

Molecular Biology
Virology
Genetics

Background:

Extrachromosomal DNA plays a role in various biological processes.
Understanding DNA circulation in vivo is crucial for disease research.

Purpose of the Study:

To investigate the biological activity and recovery of infectious viral and bacterial DNA in the bloodstream.
To explore the potential role of circulating DNA in cancer metastasis.

Main Methods:

Intraperitoneal injection of infectious polyoma virus DNA and pneumococcal transforming DNA into mice.
Recovery and biological activity assessment of DNA from blood samples.

Main Results:

Biologically active polyoma virus DNA and pneumococcal transforming DNA were recovered from mouse blood.
Polyoma DNA exhibited lower inactivation rates compared to transforming DNA.

Conclusions:

Circulating tumorigenic DNA in the bloodstream could potentially facilitate the metastatic spread of cancer.
Further research is warranted to elucidate the mechanisms and implications of circulating DNA in cancer progression.