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Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
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Effect of a restricted diet on the in vitro glucose-induced insulin release of aging rats

M Castro1, D Pedrosa, J I Osuna

  • 1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Spain.

Experientia
|October 15, 1992
PubMed

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Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...