[Effect of methaqualone on the respiration, phosphorylation and ATPase activity of rat brain mitochondria]

The authors examined the influence of the preparation metaqualone on some aspects of adrenergic metabolism-respiration, phosphorilation and ATP-ase activity of brain mitochondria of a rat in order to discover pharmacobiochemical mechanism of action. The experimental data showed that administration of metaqualon in a dose of 70 mg per kg of body weight intraperitonealy, induced a lowering of phosphorilating activity in a substrate succinate. This fact gave a foundation to suppose that in shorted respiratory chain the effect of metaqualone on the aerobic resynthesis of ATP was at a level succinat-dehydrogenase complexes. Metaqulaon induced changes in the energetic metabolism, influencing mainly of the mechanisms of the synthesis of ATP without substantial effect on the electrone transport.