Gentisate pathway in Salmonella typhimurium: metabolism of m-hydroxybenzoate and gentisate
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Updated: Aug 2, 2026

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains
Published on: January 18, 2014
1Biology Department, Mankato State University, Minnesota 56001.
Abstract:
Salmonella typhimurium was shown to use the gentisate pathway to metabolize m-hydroxybenzoate and gentisate, m-Hydroxybenzoate hydroxylase and gentisate 1,2-dioxygenase were induced by growth on either gentisate or m-hydroxybenzoate. These enzymes were not detected when the bacteria were grown with glucose or glucose and either m-hydroxybenzoate or gentisate. However, both enzymes were induced when the bacteria were grown on succinate with either substrate. The maleylpyruvate isomerase required reduced glutathione and was irreversibly inhibited by N-ethylmaleimide.
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