PARATHION POISONING FROM FLANNELETTE SHEETS

Insights

Two boys experienced severe respiratory distress due to accidental poisoning from parathion-contaminated flannelette sheets. This case highlights the dangers of organophosphate exposure and the importance of chemical testing for diagnosis.

Area of Science:

  • Toxicology
  • Environmental Health
  • Pediatrics

Background:

  • Two pediatric patients presented with coma and acute respiratory distress.
  • Initial improvement was followed by a relapse in one patient, prompting further investigation.

Purpose of the Study:

  • To identify the cause of acute poisoning in two young boys.
  • To investigate the source and nature of the toxic agent involved.

Main Methods:

  • Clinical observation and patient history.
  • Chemical analysis of household items (flannelette sheets).
  • Tracing the origin and distribution of contaminated materials.

Main Results:

  • The boys' symptoms were attributed to poisoning by organic phosphate ester, specifically parathion.
  • Contaminated flannelette sheets, exposed during ship transport, were identified as the source.
  • Parathion had been offloaded in California after a voyage from Antwerp.

Conclusions:

  • Accidental exposure to parathion can cause severe poisoning in children.
  • Environmental contamination of consumer goods poses a significant health risk.
  • Prompt chemical testing and source identification are crucial for managing such poisoning incidents.

Related Concept Videos

Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...