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Feasibility of prenatal diagnosis of beta-thalassemia using two highly polymorphic microsatellites 5' to the
G Loudianos1, A Cao, M Pirastu
1Istituto di Clinica e Biologia dell'Età Evolutiva, Università degli Studi di Cagliari, Italy.
Haematologica
|July 1, 1992
Abstract:
Short tandem repeats (STRs) are highly informative loci within the human genome, consisting of short nucleotide sequences tandemly repeated in variable numbers. This results in different alleles of variable length. Herein we describe two STRS located 5' to the beta-globin gene. They can be detected by non radioactive methods and may be used to make prenatal diagnosis of beta-thalassemia.
