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[Kaposi's sarcoma following liver transplantation]
R Oren1, D Samuel, R Tur-Kaspa
1Dept. of Medicine, Hadassah, University Hospital, Ein Karem, Jerusalem.
Harefuah
|September 1, 1992
Summary
Kaposi
Area of Science:
- Hepatology
- Transplantation Immunology
- Dermatology
Background:
- Orthotopic liver transplantation (OLT) for hepatitis B-associated cirrhosis.
- Combined immunosuppressive therapy (azathioprine, prednisone, cyclosporine A).
- Kaposi's sarcoma (KS) is rare post-liver transplant compared to kidney transplant.
Observation:
- A 54-year-old male recipient developed Kaposi's sarcoma 2 months post-OLT.
- The patient presented with cutaneous KS only, without visceral organ involvement.
- This case represents the first reported instance of KS following liver transplantation in Israel.
Findings:
- Post-transplant lymphoproliferative disorders, including KS, are associated with immunosuppression.
- The occurrence of KS post-OLT, while rare, warrants consideration in immunosuppressed patients.
- This case highlights the importance of monitoring for opportunistic infections and malignancies after OLT.
Implications:
- Clinicians should maintain a high index of suspicion for KS in liver transplant recipients on immunosuppressants.
- Early recognition and management of KS can lead to favorable outcomes, as seen in this case.
- Further research is needed to understand the specific risk factors and incidence of KS after liver transplantation.